molecular
biotechnology
laboratory
PUBLICATIONS
DISCOVERY OF NEW ANTIMICROBIALS AND OTHER SECONDARY METABOLITES
2020
CF Covas, B Almeida, AC Esteves, J Lourenço, P Domingues, T Caetano, S Mendo. (2021) Casein peptone, an antagonist of nonribosomal peptide synthesis: the case study of pedopeptins of Pedobacter lusitanus NL19. New Biotechnology, 60 62-71.
Castro I., Mendo S., Caetano T. (2020) Antibiotics from Haloarchaea: What Can We Learn from Comparative Genomics?. Marine Biotechnology, 22 , (2), 308-316.
Caetano T., van der Donk W., Mendo S. (2020) Bacteroidetes can be a rich source of novel lanthipeptides: The case study of Pedobacter lusitanus. MICROBIOLOGICAL RESEARCH, 235.
2019
Joana Barbosa, Tânia Caetano, Eva Moesker, Roderich Suessmuth, Sónia Mendo (2019) Lichenicidin rational site‐directed mutagenesis library: A tool to generate bioengineered lantibiotics. Biotechnology And Bioengineering.
2017
Covas C., Caetano T., Cruz A., Santos T., Dias L., Klein G., Abdulmawjood A., Rodriguez-Alcala L.M., Pimentel L.L., Gomes A., Freitas A.C., Garcia-Serrano A., Fontecha J., Mendo S. (2017) Pedobacter lusitanus sp nov., isolated from sludge of a deactivated uranium mine. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 67, (5), 1339-1348.
2015
Caetano T., Dias L., Pinheiro M., Mendo S. (in press) The lanthipeptides of Bacillus methylotrophicus and their association with genomic islands. Systematic And Applied Microbiology.
Barbosa, J., Caetano, T., Mendo, S. (2015). Class I and Class II Lanthipeptides Produced by Bacillus spp. Journal of natural products.
Caetano T., Sussmuth R., Mendo S. (2015) Impact of Domestication in the Production of the Class II Lanthipeptide Lichenicidin by Bacillus licheniformis I89. Current Microbiology. 70, 3, 364-368.
Santos T., Cruz A., Caetano T., Covas C., Mendo S. (2015) Draft genome sequence of Pedobacter sp. strain NL19, a producer of potent antibacterial compounds. Genome Annoucements. 3, 2, e00184-15.
2014
Caetano T., Barbosa J., Moesker E., Sussmuth R., Mendo S. (2014) Bioengineering of lanthipeptides in Escherichia coli: assessing the specificity of lichenicidin and haloduracin biosynthetic machinery. Research In Microbiology. 165, 7, 600-604.
2012
Oldach F., Al-Toma R., Kuthning A., Caetano T., Mendo S., Budisa N., Suessmuth R.D. (2012) Congeneric Lantibiotics from In Vivo Ribosomal Peptide Synthesis with non-canonical Amino Acids. Angewandte Chemie - International Edition. 51, 2, 415-418.
2011
Caetano T., Krawczyk J., Moesker E., Suessmuth R., Mendo S. (2011) Heterologous Expression, Biosynthesis, and Mutagenesis of Type II Lantibiotics from Bacillus licheniformis in Escherichia coli. Chemistry & Biology. 18, 1, 90-100.
Caetano T., Krawczyk J., Moesker E., Suessmuth R., Mendo S. (2011) Two component lantibiotics biosynthesis in E. coli: licFGEHI immunity genes are not essential for lichenicidin production and self-protection. Applied And Environmental Microbiology. 77, 14, 5023-5026.
2004 and before
Mendo S., Mendo S., Faustino N., Faustino N., Sarmento A., Sarmento A., Amado F., Amado F., Moir A., Moir A. (2004) Purification and characterization of a new peptide antibiotic produced by a thermotolerant Bacillus licheniformis strain. Biotechnology Letters. 26, 2, 115-119.
Mendo, S., Henriques I., Correia A., Duarte J. (2000) Genetic characterization of a new thermotolerant Bacillus licheniformis strain. Current Microbiology. 40, 137-139.
ENVIRONMENTAL TOXICOLOGY
2020
Fernandes S., Nogueira V., Lourenco J., Mendo S., Pereira R. (2020) Inter-species bystander effect: Eisenia fetida and Enchytraeus albidus exposed to uranium and cadmium. Journal of Hazardous Materials, 399.
Rodriguez-Seijo A., Lourenco J., Arenas-Lago D., Mendo S., Vega F.A., Pereira R. (2020) Chemical availability versus bioavailability of potentially toxic elements in mining and quarry soils. Chemosphere, 251.
Campos A., Pereira R., Vaz A., Caetano T., Malta M., Oliveira J., Carvalho F. P., Mendo S., Lourenço J. (2020) Metals and Low dose IR: molecular effects of combined exposures using HepG2 cells as a biological model. Journal Of Hazardous Materials, 396.
2019
Ofoegbu P.U., Lourenco J., Mendo S., Soares A.M.V.M., Pestana J.L.T. (2019) Effects of low concentrations of psychiatric drugs (carbamazepine and fluoxetine) on the freshwater planarian, Schmidtea mediterranea. Chemosphere, 217 542-549.
Silva A.R.R., Santos C.S.A., Ferreira N.G.C., Morgado R., Cardoso D.N., Cruz A., Mendo S., Soares A.M.V.M., Loureiro S. (2019) Multigenerational effects of carbendazim in Daphnia magna: From a subcellular to a population level. Environmental Toxicology and Chemistry, 38 , (2), 412-422.
Silva A.R.R., Cardoso D.N., Cruz A., Mendo S., Soares A.M.V.M., Loureiro S. (2019) Long-term exposure of Daphnia magna to carbendazim: how it affects toxicity to another chemical or mixture. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 26, (16), 16289-16302.
2018
Reis P., Pereira R., Carvalho F. P., Oliveira J., Malta M., Mendo S., Lourenço J. (2018) Life history traits and genotoxic effects on Daphnia magna exposed to waterborne uranium and to a uranium mine effluent - a transgenerational study. Aquatic Toxicology, 202 16-25.
Reis P., Lourenco J., Carvalho F.P., Oliveira J., Malta M., Mendo S., Pereira R. (2018) RIBE at an inter-organismic level: A study on genotoxic effects in Daphnia magna exposed to waterborne uranium and a uranium mine effluent. AQUATIC TOXICOLOGY, 198 206-214.
2017
Lourenco J., Marques S., Carvalho F.P., Oliveira J., Malta M., Santos M., Goncalves F., Pereira R., Mendo S. (2017) Uranium mining wastes: The use of the Fish Embryo Acute Toxicity Test (FET) test to evaluate toxicity and risk of environmental discharge. Science of the Total Environment, 605 391-404.
Rodrigues R., Lourenco J., Pereira P., Carvalho S., Mendo S. (2017) Effects of metal contamination on the gene expression profile of two benthic species: Cerastoderma edule and Ruditapes philippinarum. Marine Pollution Bulletin, 125 , (1-2), 157-165.
Cardoso D.N., Silva A.R.R., Cruz A., Lourenco J., Neves J., Malheiro C., Mendo S., Soares A.M.V.M., Loureiro S. (2017) The Comet Assay in Folsomia candida: a suitable approach to assess genotoxicity in collembolans. Environmental Toxicology and Chemistry, 36 , (9), 2514-2520.
Correia B., Lourenco J., Marques S., Nogueira V., Gavina A., Rasteiro M.D., Antunes F., Mendo S., Pereira R. (2017) Oxidative stress and genotoxicity of an organic and an inorganic nanomaterial to Eisenia andrei: SDS/DDAB nano -vesicles and titanium silicon oxide. Ecotoxicology and Environmental Safety, 140 198-205.
Rodriguez-Seijo A., Lourenco J., Rocha-Santos T.A.P., da Costa J., Duarte A.C., Vala H., Pereira R. (2017) Histopathological and molecular effects of microplastics in Eisenia andrei Bouche. ENVIRONMENTAL POLLUTION, 220 495-503.
Silva A.R.R., Cardoso D.N., Cruz A., Pestana J.L.T., Mendo S., Soares A.M.V.M., Loureiro S. (2017) Multigenerational effects of carbendazim in Daphnia magna. Environmental Toxicology and Chemistry, 36 , (2), 383-394.
2016
Lourenco J., Mendo S., Pereira R. (2016) Radioactively contaminated areas: Bioindicator species and biomarkers of effect in an early warning scheme for a preliminary risk assessment. Journal of Hazardous Materials, 317 503-542.
Pavlaki M.D., Araujo M.J., Cardoso D.N., Silva A.R.R., Cruz A., Mendo S., Soares A.M.V.M., Calado R., Loureiro S. (2016) Ecotoxicity and genotoxicity of cadmium in different marine trophic levels. Environmental Pollution, 215 203-212.
Ofoegbu P.U., Simao F.C.P., Cruz A., Mendo S., Soares A.M.V.M., Pestana J.L.T. (2016) Toxicity of tributyltin (TBT) to the freshwater planarian Schmidtea mediterranea. Chemosphere, 148 61-67.
2015
Lapuente J., Lourenço J., Mendo S., Borràs M., Martins M., Costa P., Pacheco M. (2015) The Comet Assay and its applications in the field of ecotoxicology: a mature tool that continues to expand its perspectives. Frontiers In Genetics.
Silva A., Cardoso D., Cruz A., Lourenco J., Mendo S., Soares A., Loureiro S. (2015) Ecotoxicity and genotoxicity of a binary combination of triclosan and carbendazim to Daphnia magna. Ecotoxicology And Environmental Safety. 115, 279-290.
2014
Silva P., Silva A., Mendo S., Loureiro S. (2014) Toxicity of tributyltin (TBT) to terrestrial organisms and its species sensitivity distribution. Science Of The Total Environment. 466–467, 1037–1046.
Gama S., Rodrigues I., Marques F., Palma E., Correia I., Carvalho M., Pessoa J., Cruz A., Mendo S., Santos I., Mendes F., Santos I., Paulo A. (2014) New ternary bipyridine-terpyridine copper(II) complexes as self-activating chemical nucleases. Rsc Advances. 4, 106, 61363-61377.
2013
Lourenço J., Pereira R., Gonçalves F., Mendo S. (2013) SSH gene expression profile of Eisenia andrei exposed in situ to a naturally contaminated soil from an abandoned uranium mine. Ecotoxicology And Environmental Safety. 88, 16–25.
Lourenço J., Pereira R., Gonçalves F., Mendo S. (2013) Metal bioaccumulation, genotoxicity and gene expression in the European wood mouse (Apodemus sylvaticus) inhabiting an abandoned uranium mining area. Science Of The Total Environment. 443, 673–680.
Pascoal S., Carvalho G., Vasieva O., Highes R., Cossins A., Fang Y., Ashelford K., Olohan L., Barroso C., Mendo S., Creer S. (2013) Transcriptomics and in vivo tests reveal novel mechanisms underlying endocrine disruption in an ecological sentinel, Nucella lapillus. Molecular Ecology. 22, 6, 1589-1608.
Lourenço J., Pereira R., Pinto F., Caetano T., Silva A., Carvalheiro T., Guimarães A., Gonçalves F., Paiva A., Mendo S. (2013) Biomonitoring a human population inhabiting nearby a deactivated uranium mine. Toxicology. 305, 8, 89-98.
Pinheiro J., Marques C., Pinto G., Mestiri A., Gomes N., Mendo S., Gonçalves F., Rocha-Santos T., Duarte A., Römbke J., Sousa J., Ksibi M., Haddioui A., Pereira R. (2013) The performance of Fraxinus angustifolia as a helper for metal phytoremediation programs and its relation to the endophytic bacterial communities. Geoderma. 202, 171-182.
2012
Lourenço J., Pereira R., Silva A., Carvalho F., Oliveira J., Malta M., Paiva A., Gonçalves F., Mendo S. (2012) Evaluation of the sensitivity of genotoxicity and cytotoxicity endpoints in earthworms exposed in situ to uranium mining wastes. Ecotoxicology And Environmental Safety. 75, 46-54.
Pascoal S., Carvalho G., Creer S., Rock J., Kawaii K., Mendo S., Hughes R. (2012) Plastic and Heritable Components of Phenotypic Variation in Nucella lapillus: An Assessment Using Reciprocal Transplant and Common Garden Experiments. Plos One. 7, 1, e30289.
2011
Lourenço J., Pereira R., Silva A., Morgado J., Carvalho F., Oliveira J., Malta M., Paiva A., Mendo S., Gonçalves F. (2011) Genotoxic endpoints in the Earthworms Sub-Lethal Assay to Evaluate Natural Soils Contaminated by Metals and Radionuclides. Journal Of Hazardous Materials. 186, 1, 788-795.
Lourenço J., Silva A., Carvalho F., Oliveira J., Malta M., Mendo S., Gonçalves F., Pereira R. (2011) Histopathological changes in the earthworm Eisenia andrei associated with the exposure to metals and radionuclides. Chemosphere. 85, 1630-1634.
2010 and before
Lourenço J., Castro B., Machado R., Nunes B., Mendo S., Gonçalves F., Pereira R. (2010) Genetic, biochemical and individual responses of the teleost fish Carassius auratus to uranium. Archives Of Environmental Contamination And Toxicology. 58, 4, 1023-1031.
Domingues I, Oliveira R, Lourenço J, Grisolia C, Mendo S, Soares A (2010) Biomarkers as a tool to assess effects of chromium (VI): Comparison of responses in zebrafish early life stages and adults. Comparative Biochemistry And Physiology, Part C. 152, 338-345.
Nogueira P., Pacheco M., Pereira M., Mendo S., Rotchell J. (2010) Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination. Environmental Pollution. 158, 5, 1783-1790.
Pereira C., Guilherme S., Barroso C., Verschaeve L., Pacheco M., Mendo S. (2010) Evaluation of DNA Damage Induced by Environmental Exposure to Mercury in Liza aurata Using the Comet Assay. Archives Of Environmental Contamination And Toxicology. 58, 1, 112-122.
Pereira R., Marques C., Silva Ferreira M., Neves M., Caetano A., Antunes S., Mendo S., Gonçalves F. (2009) Phytotoxicity and genotoxicity of soils from an abandoned uranium mine area. Applied Soil Ecology. 42, 3, 209-220.
Nogueira P., Lourenço J., Rodriguez E., Pacheco M., Santos C., Rotchell J., Mendo S. (2009) Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene. Aquatic Toxicology. 94, 2, 123-130. (see details)
Pascoal S., Creer S., Taylor M., Queiroga H., Carvalho G., Mendo S. (2009) Development and application of microsatellites in Carcinus maenas: genetic differentiation between northern and central Portuguese populations. Plos One. 4, 1, e7268.
Nogueira P., Lourenço J., Mendo S., Rotchell J. (2006) Mutation analysis of ras gene in the liver of European eel (Anguilla anguilla L.) exposed to benzo[a]pyrene. Marine Pollution Bulletin. 12, 52, 1611-1616.
Sousa A., Mendo S., Barroso C. (2005) Imposex and organotin contamination in Nassarius reticulatus (L.) along the Portuguese coast. Applied Organometallic Chemistry. 19, 315-323.
Sousa A., Génio L., Mendo S., Barroso C.M. (2005) Comparison of the acute toxicity of tributyltin (TBT) and copper to veliger larvae of Nassarius reticulatus (L.). Applied Organometallic Chemistry. 19, 324-328.
Barroso C., Mendo S., Moreira M. (2004) Organotin contamination in the mussel Mytilus galloprovincialis from Portuguese coastal waters. Marine Pollution Bulletin. 48, 1149-1153.
Mendo S., Ferreira S., Nogueira P., Silva R. (2003) Tributyltin and triphenyltin toxicity on estuarine sediment bacteria. Fresenius Environmental Bulletin. 12, 11, 1361-1367.
Bacterial resistance to xenobiotics
2020
Andrade VC, Caetano T, Mendo S, Oliveira, AJ (2020) Carbapenem resistant Enterobacteriaceae from port areas in São Paulo State (Brazil): Isolation and molecular characterization. MARINE POLLUTION BULLETIN.
2019
Dias D., Caetano T., Torres R.T., Fonseca C., Mendo S. (2019) Shiga toxin-producing Escherichia coli in wild ungulates. SCIENCE OF THE TOTAL ENVIRONMENT, 651 203-209.
Torres R.T., Fernandes J., Carvalho J., Cunha M.V., Caetano T., Mendo S., Serrano E ., Fonseca C . (2019) Wild boar as a reservoir of antimicrobial resistance. SCIENCE OF THE TOTAL ENVIRONMENT.
2018
Viana A.T., Caetano T., Covas C., Santos T., Mendo S. (2018) Environmental superbugs: The case study of Pedobacter spp. ENVIRONMENTAL POLLUTION, 241 1048-1055.
2015
Dias D., Torres R., Kronvall, G., Fonseca C., Mendo S., Caetano T. (2015) Assessment of antibiotic resistance of Escherichia coli isolates and screening of Salmonella spp. in wild ungulates from Portugal. Research In Microbiology.
Cruz A., Rodrigues R., Pinheiro M., Mendo S. (2015) Transcriptomes analysis of Aeromonas molluscorum Av27 cells exposed to tributyltin (TBT): unravelling the effects from the molecular level to the organism. Marine Environmental Research.
Cruz A., Anselmo A., Suzuki S., Mendo S. (2015) Tributyltin (TBT): A Review on Microbial Resistance and Degradation. Critical Reviews In Environmental Science And Technology. 45, 9, 970-1006.
2014
Cruz A., Moreira R., Mendo S. (2014) An easy, rapid and inexpensive method to monitor tributyltin (TBT) toxicity in the laboratory. Folia Microbiologica. 59, 3, 203-207.
Cruz A., Henriques I., Sousa A., Baptista I., Almeida A., Takahashi S., Tanabe S., Correia A., Suzuki S., Anselmo A., Mendo S. (2014) A microcosm approach to evaluate the degradation of tributyltin (TBT) by Aeromonas molluscorum Av27 in estuarine sediments. Environmental Research. 132, 430-437.
2013
Cruz A., Micaelo N., Félix V., Song J., Kitamura S., Suzuki S., Mendo S. (2013) sugE: a gene involved in tributyltin (TBT) resistance of Aeromonas molluscorum Av27. Journal Of General And Applied Microbiology. 59, 1, 39-47.
Cruz A., Areias D., Duarte A., Correia A., Suzuki A., Mendo S. (2013) Aeromonas molluscorum Av27 is a potential tributyltin (TBT) bioremediator: phenotypic and genotypic characterization indicates its safe application. Antonie Van Leeuwenhoek. 104, 385-396.
2012
Cruz A., Rodrigues R., Barroso C., Mendo S. (2012) Aeromonas molluscorum Av27 transcriptome analysis: future applications for TBT detection and remediation. Febs Journal. 279, supl. 1, 231-232.
Cruz A., Oliveira V., Baptista I., Almeida A., Cunha A., Suzuki S., Mendo S. (2012) Effect of tributyltin (TBT) in the metabolic activity of TBT-resistant and sensitive estuarine bacteria. Environmental Toxicology. 27, 1, 11-17.
2011
Santos C., Caetano T., Ferreira S., Ramalheira E., Mendo S. (2011) A novel complex class 1 integron found in a Klebsiella pneumoniae isolate from Portugal. Clinical Microbiology And Infection. 17, 7, 1036-1039.
Gonçalves O., Pereira R., Coimbra M., Gonçalves F., Mendo S., Rocha S. (2011) Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. Mutation Research-genetic Toxicology And Environmental Mutagenesis. 723, 1, 18-25.
2010
Santos, C., Caetano, T., Ferreira, S., Mendo, S. (2010) Tn5090-like class 1 integron carrying bla(VIM-2) in a Pseudomonas putida strain from Portugal. Clinical Microbiology And Infection. 16, 10, 1558-1561.
Ferreira S., Toleman M., Ramalheira E., da Silva G., Walsh T., Mendo S. (2010) First description of Klebsiella pneumoniae clinical isolates carrying both qnrA and qnrB genes in Portugal. International Journal Of Antimicrobial Agents. 35, 6, 584-586.
Ferreira S., Paradela A., Velez J., Ramalheira E., Walsh T., Mendo S. (2010) Carriage of qnrA1 and qnrB2, bla CTX-M15, and complex class 1 integron in a clinical multiresistant Citrobacter freundii isolate. Diagnostic Microbiology And Infectious Disease. 67, 2, 188-190.
Santos, C., Caetano, T., Ferreira, S., Mendo, S. (2010) First description of the blaIMP-8 in a Pseudomonas mendocina isolated in Hospital Infante D. Pedro, Aveiro, Portugal. Research Of Microbiology. 161, 4, 305-307.
2009
Rodrigues A., Pires A., Mendo S., Quintino V. (2009) Diopatra neapolitana and Diopatra marocensis from the Portuguese coast: morphological and genetic comparison. Estuarine Coastal And Shelf Science. 85, 609-617.
Ferreira E., Rosenthal A., Calado V., Saraiva J., Mendo S. (2009) Byssochlamys nivea inactivation in pineapple juice and nectar using high pressure cycles. Journal Of Food Engineering. 95, 4, 664-669.
Da Rocha E., Rosenthal A., Calado V., Saraiva J., Mendo S. (2009) Byssochlamys nivea inactivation in pineapple juice and nectar using high pressure cycles. Journal Of Food Engineering. 95, 4, 664-669.
2008 and before
Alves E., Carvalho C., Tomé J., Faustino M., Neves M., Tomé A., Cavaleiro J., Cunha Â., Mendo S., Almeida A. (2008) Photodynamic inactivation of recombinant bioluminescent Escherichia coli by cationic porphyrins under artificial and solar irradiation. Journal Of Industrial Microbiology And Biotechnology. 35, 11, 1447-1454.
Caetano T., Ferreira S., Mondego A., Correia A., Mendo S. (2007) In99 an In100 related-integron, its occurrence and prevalence in clinical Pseudomonas aeruginosa strains from Portugal. Epidemiol Infect. 135, 3, 502-504.
Cruz A., Caetano T., Suzuki S., Mendo S. (2007) Aeromonas veronii, a tributyltin (TBT)-degrading bacterium isolated from a estuarine environment, Ria de Aveiro in Portugal. Marine Environmental Research. 64, 639-650.
Correia M., Boavida F., Grosso F., Salgado M., Melo Cristino J., Mendo S., Duarte A. (2003) Molecular characterization of a new class 3 integron in Klebsiella pneumoniae. Antimicrobial Agents And Chemotherapy. 47, 9, 2838-2843.